Myositis linked to a high risk of stroke


medwireNews: People with idiopathic inflammatory myopathies (IIM) may be at increased risk for ischemic stroke, results of a systematic review and meta-analysis suggest.

Xin Wang (Qingdao Municipal Hospital, China) and her team analyzed data from six studies involving 5,114 IBD patients – including dermatomyositis, polymyositis, and sporadic body-included myositis – and more than 14 million controls .

As stated in Clinical rheumatology, people with IIM had a 2.41-fold risk of ischemic stroke compared to controls. This was mitigated to a 1.47-fold risk after excluding two studies at high risk of bias, but it was still statistically significant. When the analysis was limited to patients with dermatomyositis (four studies), these people had a risk of stroke 1.49 times higher than controls.

The results of this meta-analysis are “consistent with previous studies on the risk of ischemic stroke in patients with other [autoimmune rheumatic diseases], such as systemic lupus erythematosus and rheumatoid arthritis, ”the authors write.

They conclude: “Although better quality studies with various subtypes of IIM are needed to verify our results, our results may support that an appropriate intervention is considered for patients with IIM, particularly when it is is accompanied by other traditional risk factors for ischemic stroke. “

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Clin Rheumatol 2021; doi: 10.1007 / s10067-021-05751-2


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